Viagra Mechanism
Erectile dysfunction is a major nightmare for many men. There are many causes that are currently discussed in medical communities and university halls, and they include lifestyle, substance abuse, depression, trauma, hormonal dysfunctions, congenital defects, and other underlying conditions. The causes are also being debated as to their amount of damage, but one thing is clear, erectile dysfunction should be addressed. This life-altering scenario can even lead to deeper depression, lower self-esteem and failed marriages. Sufferers of erectile dysfunction may include very productive members of society like public officers, members of the army, political figures, businessmen, artists, scientists, and inventors. Society simply could not afford to ignore the problem faced by these men. We must allow them to buy Viagra online.
During sexual stimulation, the cavernous nerves (nerves beneath the penile shaft) release nitric oxide. Nitric oxide then induces the formation of cGMP (cyclic guanosine monophosphate) by the enzyme guanylate cyclase. The substance causes smooth muscle relaxation in the corpus cavernosum and thus making an erection. This is the chain of reactions leading to the all important erection. When a part of the chain is broken or altered, there would no erection. Of course, when there is no sexual stimulation, no nitric oxide is released. Nitric oxide is the regulator of vasodilatation and formation of the cGMP, and without which there would no resulting erection. The culprit in erectile dysfunction is phosphodiesterase type 5 (PDE5) found in the corpus cavernosa of the penis. PDE5 breakdown cGMP and thus there would be no smooth muscle relaxation in the corpus cavernosa. Viagra works by stopping PDE5 and stabilizing the erection chain. The bad guy or the PDE5 is inhibited by the active ingredient in Viagra.
Simply, the chain goes as follows: sexual stimulation ' release of nitric oxide ' formation of CGMP ' vasodilatation and relaxation of smooth muscles in the penile shaft ' erection. The problem in erectile dysfunction is the release of PDE5 which cuts the chain by inhibiting cGMP. Without cGMP, there will be no erection. viagra stabilizes the chain by stopping PDE5. From the physiology of erection, one can understand that no erection results if there is no sexual stimulation. The active ingredient of Viagra would be useless if there is no sexual stimulation.
Viagra would start working after thirty minutes to one hour from intake. The effect can last from four hours to eight hours depending on several factors like age, body built, fat content of your body, last meal, amount of stress during the day, amount of rest time and general disposition.
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