Managing Depression - Anti Depressants Treatments Are Very Efficient
There are different hypothesis which can explain the etiology of depression. Each hypothesis focuses on different biological process that contributes to explain the clinical manifestation of depression and connect the regulation of mood to other biological processes such as the stress response and feeding behavior. To control mood, these different signaling pathways converge at one point. This convergence point may control neurotransmission. There emerges the possibility that by dissecting pathways activated by anti depressants, it would be possible to find new targets for drugs with a direct and specific mechanism of action.
In many cases erectile dysfunction in men related to psychological depression did better with treatment with Viagra and treatment of depression.
Anti depressants treatments are very efficient. But still they work in only 70 to 80 % of patients and they often take more than 5 to 8 wk to elicit patient response. Moreover, current treatment methods usually have side effects and they often give partial relief which would be a risk factor for early relapse. To overcome these problems, new molecular targets for anti depressants are needed. So hypothesis based and unbiased approaches help to find these possible targets.
The unsatisfactory results of monoamine- based anti depressants therapy and the high occurrence of somatic symptoms and physical illness in patients with depression imply that the serotonin hypothesis is insufficient to approach the etiology of depression. Depression disorders with somatic presentation are the most common form of depression. The bodily symptoms without organic explanation are called as somatization. This is similar to cytokine-induced sickness behavior. Based on the recent evidence, omega-3 polyunsaturated fatty acids are help in a promising path to discover why the depression is unsolved and also to link the connection of mind and body. Eicosapentaenoic acid and docosahexaenoic acid are the major bioactive components of omega-3 polyunsaturated fatty acids, which are not efficiently synthesized in humans. Therefore, it should be directly obtained from the diet. This can be achieved by consuming fish. Docosaheaenoic acid deficiency is associated with the dysfunctions of neuronal membrane stability and transmission of serotonin, norepinephrine and dopamine. This might connect to the aetiology of mood and physical health by reducing membrane arachidonic acid and prostaglandin synthesis. This might be linked to the somatic manifestation and physical co morbidity in depression. The role of omega-3 polyunsaturated fatty acids in immunity and mood functions support the hypothesis of psychoneuroimmunolgy of depression and provide an excellent interface between the body and the mind.
Administering an effective amount of N-acetyl-serotonin (NAS) is method of treating, an obsessive compulsive disorder or anxiety in a human. A method of treating depression in a human comprising the administration of an antidepressants amount of N-acetyl –serotonin (NAS). The anti-depressant drugs are Zoloft, Paxil, and Prozac. Luvox, Celexa, Effexor, Serzone, Remeron, Lexapro and Wellbutrin. Several of these drugs are approved for the treatment of obsessive compulsive disorder in patients. Although it’s unclear whether anti depressants contribute to the emergence of suicidal thinking and behavior, these interim actions are intended to draw more attention to the need of careful monitoring of patients being treated with these drugs, especially at the beginning of therapy and during dose changes.
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