History of Viagra
Viagra was initially developed in 1993 as a treatment for angina patients. Some male test subjects began reporting erections and this prompted Pfizer to investigate further. The researchers soon concluded that the medicine is an excellent cure against erectile dysfunction and mechanism of the action is inhibiting PDE5 (Phoshodiesterase Type 5) from degrading cGMP (cyclic guanosine monophosphate). The substrate sildenafil citrate binds with the receptor in the enzyme and thus prevents the further degradation cGMP which facilitates smooth muscle contraction to give a good erection.
The Federal Bureau of Investigation approved Viagra as treatment for erectile dysfunction in April 1998 or that is six years after the initial tests. The medicine became a huge blockbuster success and Pfizer made a lot of money, some reports show that the company had $2.1 billion in Viagra sales alone during the first year of distribution. Several years later, Pfizer's major competitors Lilly Icos and Bayer came up with two erectile dysfunction drugs. Lilly produced taladafil and marketed the same as Cialis, while Bayer created vardenafil and marketed it as Levitra. The monopoly of Pfizer has been virtually destroyed and its sales plunged from almost 100% of the market to less than half these days, because of the competition from the two other major brands, new developments in erectile dysfunction drugs, and the generic versions available in online pharmacies.
Like most blockbuster drugs like Prozac and Aspirin, viagra enjoyed heavy publicity. The medicine's endorsers are the former Republican Presidential nominee Bob Dole and the Brazilian foot ball legend Pele. Some baseball players and cyclists were also rumored to be using the drug, and this prompted the governing bodies to investigate whether Viagra is a performance enhancer or not. We may have to wait for some more time before the sporting committees can provide the public with the result. However, we have new and better pharmacies in the web where we can buy viagra online .
Viagra is also the subject of many urban legends and Hollywood comedy films like Scary Movie 5. Men use to laugh at the blue pill in bar rooms and barber shops. College boys use the drug as a recreational drug for their fraternity parties. Women try the blue pill and some claim better clitoral erection after using the masculine blue pill. Many cases were filed against Pfizer in the United States because of blindness and accidents were purportedly caused by Viagra. While Pfizer on the other hand, got busier in the courts as the generic versions started to flood the market; first, they filed a case against an online pharmacy giant based in Canada, then went after sesame oil maker for allegedly copying the registered blue diamond pill design. Not only that, Pfizer is also dragging Chinese manufacturers for allegedly copying the active ingredient.
other interesting articles submitted by users:
Shopping Cart
No items in my cart
Order Total:
$ 0.00
100% Safe & Secured