Generic Nexium Has An Oral Bioavailability
Normally the stomach is protected from the acid by many mechanisms. Mainly by the layer of mucus that lines the stomach, increased blood flow to the stomach, increased levels of prostaglandins, and the repairing ability of the stomach in case of breach due to excessive acid. In spite of all these, any imbalance in the protective mechanisms would lead to the inflammation of the gastric mucosa called the gastritis. You can effectively combat this by reducing the amount of gastric acid and prevent further irritation.
Proton pump inhibitors like Generic Nexium are an effective drug in this category. It acts by reducing the hydrogen ions in the gastric acid which usually combines with chloride ions and forms the acid of the stomach. Any reduction in the hydrogen ions would automatically reduce the acid content of the stomach.
It also inhibits gastric mucosal carbonic anhydrase to some extent. Generic Nexium has an oral bioavailability of 50% as it is not stable in the acidic ph. Further the presence of food reduces its availability for which you need to take Generic Nexium on empty stomach. Compensatory increase in the amount of gastric acid may be seen initially.
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