Generic Flagyl Is Ineffective In An Aerobic Environment
Initially introduced for trichomoniasis in 1959, metronidazole later on became the drug of choice as an amoebicide. Generic Flagyl is the brand name for metronidazole that is effective against both intestinal and extra intestinal amoebiasis. It is selective in action against the anaerobic microbes and acts by diffusing into the cell. After entering the cells, a sequence of redox reactions take place that interferes with the energy metabolism of the microbes. It is important to note that Generic Flagyl is ineffective in an aerobic environment.
Though well absorbed orally and metabolized in the liver, it has a half life of 8 hours. It also acquires therapeutic concentrations in vaginal secretion, semen, saliva and the cerebrospinal fluid. If you are on this drug, then you would experience a metallic taste in the mouth which is quite normal. Other non serious side effects include loss of appetite, nausea, abdominal cramps and loose stools. It may also produce headache, glossitis, and dryness of mouth, dizziness, rashes and neutropenia. Prolonged intake may lead to peripheral neuropathy.
Pregnant women are not supposed to take this drug because of its mutagenic potential. Other contraindications are presence of neurological disease, chronic alcoholism and blood dyscrasias.
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