Generic Bactrim Is One Such Drug That Combines Sulfamethoxazole
Different anti biotics have different spectrum of action and adopt a different mechanism of action targeting specific group of microbes. If we successfully combine any two drugs with different properties and having different mechanisms, then we can get a drug having a wide spectrum of action, crossing biological barriers and attaining different concentrations in the plasma. One thing that needs to be taken care of is to find drugs that have the same goal as well as same half life. Generic Bactrim is one such drug that combines sulfamethoxazole and trimethoprim each having a half life of approximately 10 hours.
Generic Bactrim attains a synergism when combined in the ratio of 20:1. There are various advantages with this combination. You can have lower concentrations of both the drugs which will reduce the occurrences of side effects. The development of resistance will also be lower with this combination. Having an extended spectrum of action, it is useful for a large number of infections like urinary tract infections, respiratory infections, typhoid, chancroid, and bacterial diarrheas and dysentery.
One of the major disadvantages with this combination is that a contraindication to any of the two drugs will prohibit the use of Generic Bactrim.
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