Calcium Channel Blockers – ED Medications
Heart is considered to be the vital organ and it needs oxygen to pump out blood to all parts of the body. When there is low supply of oxygen to the heart, the heart strains to pump out blood and that strain causes pain in the heart. To avoid this, arteries are dilated to reduce the pressure and this is done by the calcium channel blockers. As the arteries are dilated, it becomes easier for the heart to pump out blood and the heart also consumes less oxygen. So the heart pain is reduced using calcium channel blockers (CCBs). CCBs have blood pressure lowering effect and help to treat high blood pressure. It also slows down the rate of heart beats and so it is used for treating certain types if abnormally rapid heart rhythms.
If you are planning to take erectile dysfunction medications like Generic Cialis or Generic Viagra from an online pharmacy with cardiovascular drugs you need to discuss with your physician for non-dangerous dosages. It is risky to take them with nitrate drugs.
Atrial fibrillation, paroxysmal supraventricular tachycardia is the conditions where the CCBs are mostly used. There are number of CCBs which are approved to use. Amlodipine, clevidipine, felodipine, nifedipine, diltiazem, nisodipine, nicardipine, nimodipine, isradipine, and verpamil are the CCBs approved so far. Verapamil has the widest range of approved indications, including all varieties of angina, supraventricular tachycardia and hypertension. Indirect evidence suggests that it is the one of the safest CCBs with no risks of heart block and heart failure. Verapamil is one of the numbers of early options in the therapy of hypertension. Some CCBs like amlodipine have little effect on heart rate and contraction. CCBs are classified into Dihydropyridines and non-dihydropyridines. Dihydropyridines bind to the same sites, thereby establishing their common property of calcium channel antagonism. They exert a greater inhibitory effect on vascular smooth muscle than on the myocardium. Nifedipine is the prototype of Dihydropyridine in the short-acting capsule form. It rapidly vasodilates to relieve severe hypertension and to terminate attacks of coronary spasm. The peripheral vasodilation and a rapid drop in the blood pressure lead to rapid reflex adrenergic activation with tachycardia.
CCBs are used for treating pulmonary hypertension, cardiomyopathy, subarachnoid hemorrhage, and Reynaud’s syndrome. It’s also effective in the prevention of migraine headaches. Gingival overgrowth, fluid buildup in the legs, rapid heart rate, dizziness, slow heart rate , constipation headaches and redness in the face are the side effects caused by the CCBs. Liver dysfunction, sexual dysfunction are the also the side effects of CCBs.
CCBs are classified into Dihydropyridines and non-dihydropyridines. Dihydropyridines bind to the same sites, thereby establishing their common property of calcium channel antagonism. They exert a greater inhibitory effect on vascular smooth muscle than on the myocardium. The ideal cardiovascular drug is both efficacious in reducing hard endpoints, such as mortality, stroke and myocardial infarction and its safe. Safety may be regarded as the absence of significant adverse effects when the drug is used with due regard for its known contraindications. In the case of CCBs, both efficacy and safety has been laid to rest by new studies that support the safety of long-acting CCBs, particularly in hypertension with coronary heart disease as end-point
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