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Generic Prevacid - Editorial Review

Dealing With Zollinger And Ellison Syndrome With Generic Prevacid

Discovered by Zollinger and Ellison in the 1955, it is a disorder of the gastrointestinal system characterized by increased gastric acid production and subsequent peptic ulcer. To be more specific, it is a disorder that presents with increased production of the hormone gastrin in the upper gastrointestinal system. This gastrin acts on the parietal cells of the stomach that is involved in the production of hydrogen ions for the formation of the hydrochloric acid of the stomach.

Generic Prevacid which can be ordered from an online pharmacy is one of the drugs that is used to treat Zollinger and Ellison syndrome.

The gastrin leads to the increased production of hydrogen ions as well as increases the parietal cell mass thus multiplying the production of acid. The mucosa of the stomach which is otherwise protected by mucus cannot take the excessive stress of the increased acid production and therefore leads to the formation of peptic ulcers.

Primarily increased gastrin production is from any tumor of the duodenum or pancreas that secretes the hormone gastrin. These are also called as gastrinomas. These tumors may be either single or multiple. When multiple, they usually occur as a part of a syndrome called MEN I or multiple endocrine neoplasia. These are usually small and would be distributed in the gastrointestinal symptoms with tumors of pituitary, and parathyroid. The tumors can be either benign or malignant.

It mainly presents as an epigastric pain. Sometimes diarrhea may also be associated with it. Some of the associated or aggravating factors of Zollinger Ellison syndrome symptoms are smoking, alcoholism, increased use of NSAIDs, stress and caffeine. Other symptoms include malena, vomiting and weight loss. Sometimes it can also be asymptomatic and can be an occasional finding if it is the early stages of the disease. It is advisable to meet your gastroenterologist as soon as you start experiencing the symptoms.

Usually these symptoms are not pathognomic of Zollinger Ellison syndrome and can mimic other conditions especially peptic ulcer. In such cases, you would be given preliminary treatment for ulcers. If the ulcer does not heal, then you would have to suspect for Zollinger Ellison syndrome. A diagnostic endoscopy would be very useful in arriving at the diagnosis.

There are also several laboratory tests and imaging studies that are very helpful in clinching the exact diagnosis. You can go for secretin stimulation test that helps in the measurement of increased gastrin levels. You should also measure the levels of fasting gastrin levels at least on 3 different occasions apart from measuring the gastric acid secretion and the pH level of the same.

One of the main aims of these diagnoses is to identify the source of the gastrin production. This is established by doing a MRI. Other method is somatostatin receptor scintigraphy.

Once the tumor is found, it has to be removed either surgically or by chemotherapy. Then octreotide can be given to gain relief from the symptoms. Then our next motive is to reduce the gastric acid production which can be done using proton pump inhibitors and H-2 receptor antagonists. The prognosis is good.